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P428 Optimizing thiopurines in Crohns disease: low dose and low 6-TGN level are effective for maintenance of remission in Asian population

Liu et al (33) demonstrated that chronic treatment with GLP-1 or AC3174 improves glucose metabolism, fluid balance and respiratory efficiency in a rat model of congestive heart failure, compared with vehicle control animals

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Semaglutide injection works through a mechanism that begins almost immediately after administration, activating GLP-1 receptors in your brain to signal fullness and reduce food cravings

Additionally, the kindling model is not well standardized in zebrafish, as the existing studies only exposed the animals to chronic low doses of PTZ and evaluated the seizure behavior just after the exposure